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GABAergic neurons in the ventral lateral geniculate nucleus and intergeniculate leaflet are involved in itch processing in mice.
Liang, Yi; Fan, Ze; Li, Jiaqi; Ma, Ruiyu; Zhang, Yiwen; Shi, Xiaotong; Zhu, Yuanyuan; Huang, Jing.
Afiliação
  • Liang Y; Department of Neurobiology, Basic Medical Science Academy, Fourth Military Medical University, Xi'an, 710032, China.
  • Fan Z; Department of Neurobiology, Basic Medical Science Academy, Fourth Military Medical University, Xi'an, 710032, China; State Key Laboratory of Military Stomatology, Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, China.
  • Li J; Department of Neurobiology, Basic Medical Science Academy, Fourth Military Medical University, Xi'an, 710032, China.
  • Ma R; The Cadet Team of Basic Medical Science Academy, Fourth Military Medical University, Xi'an, 710032, China.
  • Zhang Y; The Cadet Team of Basic Medical Science Academy, Fourth Military Medical University, Xi'an, 710032, China.
  • Shi X; State Key Laboratory of Military Stomatology, Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, China.
  • Zhu Y; Department of Neurobiology, Basic Medical Science Academy, Fourth Military Medical University, Xi'an, 710032, China.
  • Huang J; Department of Neurobiology, Basic Medical Science Academy, Fourth Military Medical University, Xi'an, 710032, China. Electronic address: jinghuang@fmmu.edu.cn.
Biochem Biophys Res Commun ; 659: 72-79, 2023 06 04.
Article em En | MEDLINE | ID: mdl-37054505
Itch and pain are two closely related sensations that receiving similar encodings at multiple levels. Accumulated evidences suggest that activation of the ventral lateral geniculate nucleus and intergeniculate leaflet (vLGN/IGL)-to-lateral and ventrolateral periaqueductal gray (l/vlPAG) projections mediates the antinociceptive effects of bright light therapy. Clinical study showed that bright light therapy may ameliorate cholestasis-induced pruritus. However, the underlying mechanism and whether this circuit participates in itch modulation remains unclear. In this study, chloroquine and histamine were utilized to induce acute itch models in mice. Neuronal activities in vLGN/IGL nucleus were evaluated with c-fos immunostaining as well as fiber photometry. Optogenetic manipulations were performed to activate or inhibit GABAergic neurons in the vLGN/IGL nucleus. Our results showed that the expressions of c-fos in vLGN/IGL were significantly increased upon both chloroquine- and histamine-induced acute itch stimuli. GABAergic neurons in vLGN/IGL were activated during histamine and chloroquine-induced scratching. Optogenetic activation of the vLGN/IGL GABAergic neurons exerts antipruritic effect, while inhibiting these neurons exerts pruritic effect. Our results provide evidence that GABAergic neurons in vLGN/IGL nucleus might play a crucial role in modulating itch, which may provide clue for application of bright light as an antipruritic treatment in clinic.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Histamina / Corpos Geniculados Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Histamina / Corpos Geniculados Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article