Achievement of operational tolerance in a pediatric liver transplant recipient following successful hematopoietic stem cell transplantation from a different donor.
Am J Transplant
; 23(9): 1446-1450, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-37061187
ABSTRACT
Hematopoietic stem cell transplantation (HSCT)-based approaches are increasingly investigated strategies to induce tolerance in recipients of solid allografts. However, in the majority of cases, these approaches rely on the infusion of hematopoietic stem cells recovered from the same solid organ donor. In this report, we describe the case of a boy who received liver transplantation from a deceased donor, who had successfully underwent allogeneic HSCT from an unrelated donor for hepatitis-associated aplastic anemia. In this patient, it was possible to permanently withdraw post-HSCT immune suppression without causing any sign of liver graft dysfunction. To the best of our knowledge, this is the first case of operational tolerance documented in a patient who received combined liver transplantation and HSCT from different donors.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transplante de Fígado
/
Transplante de Células-Tronco Hematopoéticas
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Doença Enxerto-Hospedeiro
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Anemia Aplástica
Tipo de estudo:
Etiology_studies
Limite:
Child
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article