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Boron uptake of boronophenylalanine and the effect of boron neutron capture therapy in cervical cancer cells.
Terada, Shinichi; Tsunetoh, Satoshi; Tanaka, Yoshimichi; Tanaka, Tomohito; Kashiwagi, Hideki; Takata, Takushi; Kawabata, Shinji; Suzuki, Minoru; Ohmichi, Masahide.
Afiliação
  • Terada S; Department of Obstetrics and Gynecology, Osaka Medical and Pharmaceutical University, Takatsuki, Japan. Electronic address: shinichi.terada@ompu.ac.jp.
  • Tsunetoh S; Department of Obstetrics and Gynecology, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
  • Tanaka Y; Department of Obstetrics and Gynecology, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
  • Tanaka T; Department of Obstetrics and Gynecology, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
  • Kashiwagi H; Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
  • Takata T; Institute for Integrated Radiation and Nuclear Science, Kyoto University, Asasiro-Nishi, Kumatori-cho, Japan.
  • Kawabata S; Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
  • Suzuki M; Institute for Integrated Radiation and Nuclear Science, Kyoto University, Asasiro-Nishi, Kumatori-cho, Japan.
  • Ohmichi M; Department of Obstetrics and Gynecology, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Appl Radiat Isot ; 197: 110792, 2023 Jul.
Article em En | MEDLINE | ID: mdl-37062147
ABSTRACT
There are few studies about boron neutron capture therapy (BNCT) for cervical cancer. The present study evaluated the biodistribution of boronophenylalanine (BPA) and the effect of BNCT on cervical cancer cell lines. BPA exposure and neutron irradiation of cervical cancer cell lines resulted in decreased survival fraction compared to irradiation only. In vivo cervical cancer tumor boron concentration was highest at 2.5 h after BPA intraperitoneal administration, and higher than in the other organs. BNCT may be effective against cervical carcinoma.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / Terapia por Captura de Nêutron de Boro Limite: Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / Terapia por Captura de Nêutron de Boro Limite: Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article