Photothermal-Responsive Intelligent Hybrid of Hierarchical Carbon Nanocages Encapsulated by Metal-Organic Hydrogels for Sensitized Photothermal Therapy.
Adv Healthc Mater
; 12(26): e2300834, 2023 10.
Article
em En
| MEDLINE
| ID: mdl-37062751
ABSTRACT
Hierarchical carbon nanocages as emerging nanomaterials have a great potential for photothermal therapy due to their unique porous structure, high specific surface area, and excellent photothermal property. Herein, a hierarchical nitrogen-doped carbon nanocage (hNCNC) is introduced as a second near-infrared photothermal agent, and then functionalizes it with metal-organic hydrogel (MOG) to form a thermal-responsive switch for sensitized photothermal therapy. Upon 1064 nm light irradiation, the hNCNCs exhibit a remarkable photothermal conversion efficiency of 65.9% owing to a high near-infrared extinction coefficient. Meanwhile, due to the hierarchical structure, hNCNCs show 60.2% (wt./wt.) loading efficiency of quercetin, a heat shock protein (Hsp70) inhibitor. Through thermal-driven dry-gel transformation, the coating MOGs intelligently release the encapsulated quercetin for sensitizing cancer cells to heat. Based on the synergistic effect of hyperthermia elevation and thermal-driven drug release, the dual thermal utilization platform achieves effective photothermal tumor ablation in vivo under low concentration of hNCNCs and mild irradiation, which provides a new diagram of intelligent responsive photothermal agents for enhanced photothermal therapy.
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MEDLINE
Assunto principal:
Carbono
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Hipertermia Induzida
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article