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Dysregulation of systemic soluble immune checkpoints in early breast cancer is attenuated following administration of neoadjuvant chemotherapy and is associated with recovery of CD27, CD28, CD40, CD80, ICOS and GITR and substantially increased levels of PD-L1, LAG-3 and TIM-3.
Rapoport, Bernardo L; Steel, Helen C; Benn, Carol A; Nayler, Simon; Smit, Teresa; Heyman, Liezl; Theron, Annette J; Hlatshwayo, Nomsa; Kwofie, Luyanda L I; Meyer, Pieter W A; Anderson, Ronald.
Afiliação
  • Rapoport BL; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
  • Steel HC; Medical Oncology Centre of Rosebank, Johannesburg, South Africa.
  • Benn CA; Netcare Breast Care Centre, Johannesburg, South Africa.
  • Nayler S; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
  • Smit T; Netcare Breast Care Centre, Johannesburg, South Africa.
  • Heyman L; Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Theron AJ; Netcare Breast Care Centre, Johannesburg, South Africa.
  • Hlatshwayo N; Drs Gritzman & Thatcher Inc. Laboratories, University of the Witwatersrand Donald Gordon Medical Centre, Johannesburg, South Africa.
  • Kwofie LLI; Medical Oncology Centre of Rosebank, Johannesburg, South Africa.
  • Meyer PWA; Medical Oncology Centre of Rosebank, Johannesburg, South Africa.
  • Anderson R; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Front Oncol ; 13: 1097309, 2023.
Article em En | MEDLINE | ID: mdl-37064132
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article