Safety and real-world efficacy of lemborexant in the treatment of comorbid insomnia.
Sleep Med X
; 5: 100070, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-37065177
ABSTRACT
Aim:
To investigate the real-world effectiveness and safety of lemborexan for treating comorbid insomnia associated with other psychiatric disorders, and whether lemborexant helps reduce the dose of benzodiazepines (BZs).Methods:
This retrospective observational study was conducted on outpatients and inpatients treated by physicians of Juntendo University Hospital Mental Clinic between April 2020 and December 2021.Results:
Data of 649 patients who were treated with lemborexant were eventually enrolled. About 64.5% of patients were classified as the responder group. Response rates of ≥60% were recorded for most psychiatric disorders. Upon administration of lemborexant, diazepam-equivalent dose of BZs had been significantly reduced in participants (3.7 ± 8.2 vs. 2.9 ± 7.9, p < 0.001). The results of logistic regression analysis showed that outpatient (odds ratios 2.310; 95% confidence interval [CI] 1.32-4.05), shorter duration of BZ use (<1 year) (odds ratios 1.512; 95% CI 1.02-2.25), no adverse events (odds ratios 10.369; 95% CI 6.13-17.54), larger reduction of diazepam-equivalent dose of BZs upon introducing lemborexant prescription (odds ratios 1.150; 95% CI 1.04-1.27), and suvorexant was the replacement drug (odds ratios 2.983; 95% CI 1.44-6.19), which were significant predictors of good response.Conclusion:
Although this is a retrospective and observational study with many limitations, our study results suggest that lemborexant is effective and safe.
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Base de dados:
MEDLINE
Tipo de estudo:
Observational_studies
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article