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Hemophagocytic Lymphohistiocytosis Caused by a Severe Epstein-Barr Virus Infection in a Young Patient Presenting With Hiccups.
Abou-El-Hassan, Hadi; Kantono, Melvin; Bhagat, Ankur; Hu, Janie; Karp, David; Jerome, Renard; Randhawa, Johnny S; Shafer, Drake; Farmand, Farbod.
Afiliação
  • Abou-El-Hassan H; Neurology, Arrowhead Regional Medical Center, Colton, USA.
  • Kantono M; Internal Medicine, Arrowhead Regional Medical Center, Colton, USA.
  • Bhagat A; Internal Medicine, Arrowhead Regional Medical Center, Colton, USA.
  • Hu J; Internal Medicine, Arrowhead Regional Medical Center, Colton, USA.
  • Karp D; Internal Medicine, Arrowhead Regional Medical Center, Colton, USA.
  • Jerome R; Internal Medicine, Arrowhead Regional Medical Center, Colton, USA.
  • Randhawa JS; Internal Medicine, Arrowhead Regional Medical Center, Colton, USA.
  • Shafer D; Internal Medicine, California University of Science and Medicine, Colton, USA.
  • Farmand F; Internal Medicine, Arrowhead Regional Medical Center, Colton, USA.
Cureus ; 15(3): e36199, 2023 Mar.
Article em En | MEDLINE | ID: mdl-37065339
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome characterized by a pathologic immune response in the setting of infection, malignancy, acute illness, or any immunological stimulus. Infection is the most common etiology of HLH. HLH involves aberrant activation of lymphocytes and macrophages with resultant hypercytokinemia due to an inappropriately stimulated and ineffective immune response. Here, we present the case of a previously healthy 19-year-old male presenting with hiccups and scleral icterus, who was found to have HLH due to a severe Epstein-Barr virus infection. Despite a morphologically normal bone marrow biopsy, the patient met the diagnostic criteria for HLH, including a low natural killer cell count and elevated soluble interleukin-2 receptor. Notably, ferritin was severely elevated at 85,810 ng/mL. The patient was treated with an induction course of dexamethasone intravenously for eight weeks. Since HLH can progress into multi-organ failure, timely diagnosis and prompt initiation of treatment are critical. Novel disease-modifying therapies and further clinical trials are warranted to treat this potentially fatal immunological disease with multisystem ramifications.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article