Microwave hyperthermia represses human papillomavirus oncoprotein activity and induces cell death due to cell stress in 3D tissue models of anogenital precancers and cancers.

Conley, Michaela J; Epifano, Ilaria; Kirk, Anna; Stevenson, Andrew; Graham, Sheila V

Conley, Michaela J; Epifano, Ilaria; Kirk, Anna; Stevenson, Andrew; Graham, Sheila V.

Afiliação

Conley MJ; MRC-University of Glasgow Centre for Virus Research; School of Infection and Immunity; College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Estate, Glasgow, G61 1QH, Scotland, UK.
Epifano I; MRC-University of Glasgow Centre for Virus Research; School of Infection and Immunity; College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Estate, Glasgow, G61 1QH, Scotland, UK.
Kirk A; MRC-University of Glasgow Centre for Virus Research; School of Infection and Immunity; College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Estate, Glasgow, G61 1QH, Scotland, UK.
Stevenson A; MRC-University of Glasgow Centre for Virus Research; School of Infection and Immunity; College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Estate, Glasgow, G61 1QH, Scotland, UK.
Graham SV; MRC-University of Glasgow Centre for Virus Research; School of Infection and Immunity; College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Estate, Glasgow, G61 1QH, Scotland, UK. Electronic address: sheila.graham@glasgow.ac.uk.

EBioMedicine ; 91: 104577, 2023 May.

Article em En | MEDLINE | ID: mdl-37068348

Assuntos

Hipertermia Induzida; Proteínas Oncogênicas Virais; Infecções por Papillomavirus; Neoplasias do Colo do Útero; Feminino; Humanos; Papillomavirus Humano; Micro-Ondas; Infecções por Papillomavirus/complicações; Infecções por Papillomavirus/terapia; Proteínas Oncogênicas Virais/genética; Proteínas Oncogênicas Virais/metabolismo; Neoplasias do Colo do Útero/terapia; Neoplasias do Colo do Útero/genética; Morte Celular; Proteínas E7 de Papillomavirus/genética

Palavras-chave

Cell stress response; Cervical disease; HSP70; Human papillomavirus; Microwave hyperthermia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / Proteínas Oncogênicas Virais / Infecções por Papillomavirus / Hipertermia Induzida Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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