Survival outcomes in veterans with hepatocellular carcinoma, with and without HIV infection.
AIDS
; 37(9): 1387-1397, 2023 07 15.
Article
em En
| MEDLINE
| ID: mdl-37070557
ABSTRACT
BACKGROUND:
HIV infection has been associated with survival disparities among persons with hepatocellular carcinoma (HCC). However, most studies examining survival do not control for provider (e.g. type of HCC treatment given) or individual-level factors (e.g. homelessness, substance use) that could impact survival. In this study, we evaluate the effect of HIV status on survival among persons with HCC, in a comprehensive model that accounts for key individual, provider, and systems-level factors.METHODS:
We conducted a retrospective cohort study of persons with HIV (PWH) matched 1ââ1 to HIV-negative controls based on age and year of HCC diagnosis in the national Veterans Administration (VA) health system. The primary outcome was survival. We used Cox regression models to evaluate the effect of HIV status on risk of death.RESULTS:
This cohort included 200 matched pairs diagnosed with HCC between 2009 and 2016. A total of 114 PWH (57.0%) and 115 HIV-negative patients (57.5%) received guideline-concordant therapy ( P â=â0.92). Median survival was 13.4âmonths [95% confidence interval (CI) 8.7-18.1] among PWH and 19.1âmonths (95% CI 14.6-24.9) for HIV-negative patients. In adjusted models, older age, homelessness, advanced Barcelona Clinic Liver Cancer (BCLC) stage, and not receiving any HCC treatment predicted risk of death. HIV status was not associated with risk of death [adjusted hazard ratio (aHR) 0.95; 95% CI 0.75-1.20; P â=â0.65].CONCLUSION:
HIV status was not associated with worse survival among HCC patients, in a single-payer, equal access healthcare system. These results suggest that HIV infection alone should not exclude PWH from receiving standard therapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Veteranos
/
Infecções por HIV
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Carcinoma Hepatocelular
/
Neoplasias Hepáticas
Tipo de estudo:
Guideline
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article