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Real-world discontinuations due to neuropsychiatric symptoms in people living with HIV treated with second-generation integrase inhibitors: a systematic review.
Pérez-Valero, Ignacio; Corona, Diana; Martínez, Natalia; López-Cavanillas, María; Lluis, Carla; Luque, Isabel.
Afiliação
  • Pérez-Valero I; Servicio de Enfermedades Infecciosas, Hospital Universitario Reina Sofía, Córdoba, Spain. Grupo de Virología Clínica y Zoonosis, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain. CIBERINFEC, ISCIII - CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III,
  • Corona D; Servicio de Enfermedades Infecciosas, Hospital Universitario Reina Sofía, Córdoba, Spain. Grupo de Virología Clínica y Zoonosis, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain. CIBERINFEC, ISCIII - CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III,
  • Martínez N; Medical Affairs HIV, Gilead Sciences, Madrid, Spain.
  • López-Cavanillas M; Medical Affairs HIV, Gilead Sciences, Madrid, Spain.
  • Lluis C; Medical Affairs HIV, Gilead Sciences, Madrid, Spain.
  • Luque I; Medical Affairs HIV, Gilead Sciences, Madrid, Spain.
Expert Rev Anti Infect Ther ; 21(6): 655-665, 2023 06.
Article em En | MEDLINE | ID: mdl-37074798
ABSTRACT

INTRODUCTION:

Second-generation integrase strand transfer inhibitors such as bictegravir (BIC) and dolutegravir (DTG) are the standard of care for starting therapy in people living with HIV (PLHIV). However, their use has been associated with neuropsychiatric symptoms (NPSs) that may lead to treatment discontinuation. We aim to describe and synthesize information on safety and discontinuation rates and to summarize potential risk factors associated with the development of NPSs in PLHIV treated with these regimens. AREAS COVERED A systematic review of the literature was carried out in the international databases PubMed/Medline, Web of Science (WoS), Scopus, Embase, and Cochrane Library from 2013 to June 2022. Ninety observational studies reporting data on treatment discontinuation due to drug-related adverse events and NPSs were identified. EXPERT OPINION Discontinuation rates due to NPSs increase with treatment time and, in light of the reviewed studies, are higher in PLHIV treated with DTG-based regimens compared with those treated with BIC/emtricitabine/tenofovir alafenamide fumarate (BIC/FTC/TAF). This information could be useful for clinicians during treatment decision-making, reducing discontinuation rates and thereby promoting treatment success and durability. Additionally, the identification of potential risk factors in PLHIV prior to starting therapy could also help make the best therapy choices based on the characteristics of each individual.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Inibidores de Integrase de HIV / Fármacos Anti-HIV Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Inibidores de Integrase de HIV / Fármacos Anti-HIV Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article