Dangerous liaisons: how helminths manipulate the intestinal epithelium.
Trends Parasitol
; 39(6): 414-422, 2023 06.
Article
em En
| MEDLINE
| ID: mdl-37076358
ABSTRACT
Intestinal helminths remain highly pervasive throughout the animal kingdom by modulating multiple aspects of the host immune response. The intestinal epithelium functions as a physical barrier as well as a sentinel innate immune tissue with the ability to sense and respond to infectious agents. Although helminths form intimate interactions with the epithelium, comprehensive knowledge about host-helminth interactions at this dynamic interface is lacking. In addition, little is known about the ability of helminths to directly shape the fate of this barrier tissue. Here, we review the diverse pathways by which helminths regulate the epithelium and highlight the emerging field of direct helminth regulation of intestinal stem cell (ISC) fate and function.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Helmintíase
/
Helmintos
/
Enteropatias Parasitárias
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article