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Biomarkers of aging.
Bao, Hainan; Cao, Jiani; Chen, Mengting; Chen, Min; Chen, Wei; Chen, Xiao; Chen, Yanhao; Chen, Yu; Chen, Yutian; Chen, Zhiyang; Chhetri, Jagadish K; Ding, Yingjie; Feng, Junlin; Guo, Jun; Guo, Mengmeng; He, Chuting; Jia, Yujuan; Jiang, Haiping; Jing, Ying; Li, Dingfeng; Li, Jiaming; Li, Jingyi; Liang, Qinhao; Liang, Rui; Liu, Feng; Liu, Xiaoqian; Liu, Zuojun; Luo, Oscar Junhong; Lv, Jianwei; Ma, Jingyi; Mao, Kehang; Nie, Jiawei; Qiao, Xinhua; Sun, Xinpei; Tang, Xiaoqiang; Wang, Jianfang; Wang, Qiaoran; Wang, Siyuan; Wang, Xuan; Wang, Yaning; Wang, Yuhan; Wu, Rimo; Xia, Kai; Xiao, Fu-Hui; Xu, Lingyan; Xu, Yingying; Yan, Haoteng; Yang, Liang; Yang, Ruici; Yang, Yuanxin.
Afiliação
  • Bao H; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China.
  • Cao J; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Chen M; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China.
  • Chen M; Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, 410008, China.
  • Chen W; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.
  • Chen X; Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Chen Y; Hubei Clinical Research Center of Metabolic and Cardiovascular Disease, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Chen Y; Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Chen Y; Stem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
  • Chen Z; Department of Nuclear Medicine, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
  • Chhetri JK; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
  • Ding Y; Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji Un
  • Feng J; The Department of Endovascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
  • Guo J; Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Ageing and Regenerative Medicine, Jinan University, Guangzhou, 510632, China.
  • Guo M; National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
  • He C; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China.
  • Jia Y; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Jiang H; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China.
  • Jing Y; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, China.
  • Li D; School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
  • Li J; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Li J; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Liang Q; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
  • Liang R; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.
  • Liu F; Department of Neurology, First Affiliated Hospital, Shanxi Medical University, Taiyuan, 030001, China.
  • Liu X; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Liu Z; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Luo OJ; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
  • Lv J; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.
  • Ma J; Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
  • Mao K; Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
  • Nie J; Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China.
  • Qiao X; Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, China.
  • Sun X; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China.
  • Tang X; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Wang J; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Wang Q; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Wang S; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
  • Wang X; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.
  • Wang Y; College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430072, China.
  • Wang Y; Research Institute of Transplant Medicine, Organ Transplant Center, NHC Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, Nankai University, Tianjin, 300384, China.
  • Wu R; MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research, School of Life Sciences, Institute of Healthy Aging Research, Sun Yat-sen University, Guangzhou, 510275, China.
  • Xia K; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Xiao FH; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Xu L; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
  • Xu Y; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.
  • Yan H; School of Life Sciences, Hainan University, Haikou, 570228, China.
  • Yang L; Department of Systems Biomedical Sciences, School of Medicine, Jinan University, Guangzhou, 510632, China.
  • Yang R; School of Life Sciences, Xiamen University, Xiamen, 361102, China.
  • Yang Y; The State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Sci China Life Sci ; 66(5): 893-1066, 2023 05.
Article em En | MEDLINE | ID: mdl-37076725
ABSTRACT
Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although a broad spectrum of aging biomarkers has been developed, their potential uses and limitations remain poorly characterized. An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research How old are we? Why do we get old? And how can we age slower? This review aims to address this need. Here, we summarize our current knowledge of biomarkers developed for cellular, organ, and organismal levels of aging, comprising six pillars physiological characteristics, medical imaging, histological features, cellular alterations, molecular changes, and secretory factors. To fulfill all these requisites, we propose that aging biomarkers should qualify for being specific, systemic, and clinically relevant.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Senescência Celular Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Senescência Celular Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article