High-throughput AR dimerization assay identifies androgen disrupting chemicals and metabolites.

Brown, Evan C; Hallinger, Daniel R; Simmons, Steven O

Brown, Evan C; Hallinger, Daniel R; Simmons, Steven O.

Afiliação

Brown EC; Oak Ridge Institute for Science Education Fellow, Research Triangle Park, NC, United States.
Hallinger DR; Rapid Assay Development Branch, Biomolecular and Computational Toxicology Division, Center for Computational Toxicology and Exposure, Office of Research and Development, U. S. Environmental Protection Agency, Research Triangle Park, NC, United States.
Simmons SO; Rapid Assay Development Branch, Biomolecular and Computational Toxicology Division, Center for Computational Toxicology and Exposure, Office of Research and Development, U. S. Environmental Protection Agency, Research Triangle Park, NC, United States.

Front Toxicol ; 5: 1134783, 2023.

Article em En | MEDLINE | ID: mdl-37082740

Palavras-chave

CYP450; agonist; androgen receptor; antagonist; endocrine; high-throughput (HT) screening; metabolism; new approach methodologies (NAMs)

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article