Perceived stress and markers of ovarian reserve among subfertile women.
Reprod Biomed Online
; 46(6): 956-964, 2023 06.
Article
em En
| MEDLINE
| ID: mdl-37085427
ABSTRACT
RESEARCH QUESTION Is self-reported psychological stress associated with markers of ovarian reserve among subfertile women? DESIGN:
Observational study of women (nâ¯=â¯520) seeking fertility care at the Massachusetts General Hospital who enrolled in the Environment and Reproductive Health study between 2005 and 2019. Women completed the short version of the validated PSS4, which assesses psychological stress. Ovarian reserve markers included AFC and circulating serum levels of day-3 FSH, with AMH assessed in a subset of participants (nâ¯=â¯185).RESULTS:
Higher total PSS4 scores were negatively associated with AFC and serum AMH levels. Analyses adjusted for age, BMI, race, smoking, education, physical activity and type of infertility diagnosis. Women in the second and third tertiles of stress had lower AFC (13.3, 95% CI 12.7 to 13.8; and 13.5, 95% CI 13.0 to 14.1) compared with women in the lowest tertile of psychological stress score (14.3, 95% CI 13.8 to 14.9, both P < 0.05). Women in the second and third tertiles of total PSS4 scores also had lower mean serum AMH compared with women in the lowest tertile (2.99, 95% CI 2.24 to 3.74), and (2.99 95% CI 2.22 to 3.76) versus (3.94 95% CI 3.23 to 4.64). These associations varied by several socioeconomic factors, and were observed among women who were younger, belonging to minority races, with a college degree or with annual household income less than $100,000.CONCLUSIONS:
Higher perceived stress was negatively associated with AFC and serum AMH levels. These associations varied by several socioeconomic factors.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Reserva Ovariana
/
Infertilidade Feminina
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article