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The chemotherapeutic drug doxorubicin does not exacerbate p16Ink4a-positive senescent cell accumulation and cardiometabolic disease development in young adult female LDLR-deficient mice.
Postmus, Andrea C; Kruit, Janine K; Eilers, Roos E; Havinga, Rick; Koster, Mirjam H; Johmura, Yoshikazu; Nakanishi, Makoto; van de Sluis, Bart; Jonker, Johan W.
Afiliação
  • Postmus AC; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Kruit JK; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Eilers RE; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Havinga R; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Koster MH; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Johmura Y; Division of Cancer and Senescence Biology, Cancer Research Institute, Institute for Frontier Science Initiative, Kanazawa University, Kakuma, Kanazawa, Japan.
  • Nakanishi M; Division of Cancer Cell Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • van de Sluis B; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Jonker JW; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: j.w.jonker@umcg.nl.
Toxicol Appl Pharmacol ; 468: 116531, 2023 06 01.
Article em En | MEDLINE | ID: mdl-37088304
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Inibidor p16 de Quinase Dependente de Ciclina Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Inibidor p16 de Quinase Dependente de Ciclina Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article