A rare case of schizophrenia coexistence with antiphospholipid syndrome, ß-thalassemia, and monoclonal gammopathy of undetermined significance.
Front Psychiatry
; 14: 1178247, 2023.
Article
em En
| MEDLINE
| ID: mdl-37091711
ABSTRACT
A patient with schizophrenia who was treated with chlorpromazine developed lupus anticoagulant (LA) and antiphospholipid syndrome (APS). On protein electrophoresis, a monoclonal immunoglobulin A peak was seen in this patient, defining a condition of monoclonal gammopathy of undetermined significance. Additionally, ß-thalassemia was diagnosed with the CD41-42 genotype. This condition is extremely rare, particularly in patients with schizophrenia and APS. We present a case of a patient with schizophrenia and secondary APS who had a positive LA, a significantly prolonged activated partial thromboplastin time, endogenous coagulation factor deficiency and inhibitor, no bleeding, and an unexpected finding of ß-thalassemia and monoclonal IgA. Following that, a literature review on the disorders was presented.
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Ano de publicação:
2023
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Article