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Application of an "inhalation by design" approach to the identification and in-vitro evaluation of novel purine based PI3Kδ inhibitors.
Mazzucato, Roberta; Roberti, Marinella; Capelli, Anna Maria; Rancati, Fabio; Biagetti, Matteo; Fiorelli, Claudio; Bruno, Paolo; Ronchi, Paolo; Bertolini, Serena; Corsi, Mauro; Pala, Daniele.
Afiliação
  • Mazzucato R; Chemistry Research and Drug Design Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122, Parma, Italy. Electronic address: R.Mazzucato@chiesi.com.
  • Roberti M; Department of Pharmacy and Biotechnology, University of Bologna, 40126, Bologna, Italy.
  • Capelli AM; Corporate Drug Development, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122, Parma, Italy.
  • Rancati F; Chemistry Research and Drug Design Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122, Parma, Italy.
  • Biagetti M; Pipeline Innovation Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122, Parma, Italy.
  • Fiorelli C; Chemistry Research and Drug Design Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122, Parma, Italy.
  • Bruno P; Chemistry Research and Drug Design Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122, Parma, Italy.
  • Ronchi P; Chemistry Research and Drug Design Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122, Parma, Italy.
  • Bertolini S; Experimental Pharmacology and Translational Science, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122, Parma, Italy.
  • Corsi M; In Vitro Biology Department, Aptuit, an Evotec Company, Via A. Fleming 4, 37135, Verona, Italy.
  • Pala D; Chemistry Research and Drug Design Department, Chiesi Farmaceutici S.p.A, Nuovo Centro Ricerche, Largo Belloli 11/a, 43122, Parma, Italy. Electronic address: d.pala@chiesi.com.
Eur J Med Chem ; 254: 115331, 2023 Jun 05.
Article em En | MEDLINE | ID: mdl-37094451
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Asma / Doença Pulmonar Obstrutiva Crônica Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Asma / Doença Pulmonar Obstrutiva Crônica Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article