Alcohol, the gut microbiome, and liver disease.
J Gastroenterol Hepatol
; 38(8): 1205-1210, 2023 Aug.
Article
em En
| MEDLINE
| ID: mdl-37096652
ABSTRACT
The microorganisms inhabiting our gastrointestinal tract are critical for human health. Chronic heavy alcohol use can modulate the composition and function of the gut microbiota, thereby exacerbating end-organ damage via the gut-brain axis and the gut-liver axis. In this review, we summarize the bacterial, fungal, and viral gut microbial compositional changes associated with alcohol use and alcohol-associated liver disease and discuss the mechanisms of action by which gut dysbiosis reinforces alcohol use behavior and liver inflammation and injury. We also highlight important pre-clinical and clinical trials that target gut microbial-specific mechanisms for the treatment of alcohol use disorder and alcohol-associated liver disease.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Alcoolismo
/
Microbioma Gastrointestinal
/
Hepatopatias Alcoólicas
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article