Apolipoprotein M supports S1P production and conservation and mediates prolonged Akt activation via S1PR1 and S1PR3.

Kiyozuka, Keisuke; Zhao, Xian; Konishi, Akimitsu; Minamishima, Yoji Andrew; Obinata, Hideru

Kiyozuka, Keisuke; Zhao, Xian; Konishi, Akimitsu; Minamishima, Yoji Andrew; Obinata, Hideru.

Afiliação

Kiyozuka K; Department of Biochemistry, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.
Zhao X; Department of Biochemistry, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.
Konishi A; Department of Biochemistry, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.
Minamishima YA; Department of Biochemistry, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.
Obinata H; Education and Research Support Center, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.

J Biochem ; 174(3): 253-266, 2023 Jul 31.

Article em En | MEDLINE | ID: mdl-37098187

Assuntos

Lisofosfolipídeos; Proteínas Proto-Oncogênicas c-akt; Humanos; Apolipoproteínas M/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Lisofosfolipídeos/farmacologia; Esfingosina/farmacologia; Proteínas de Transporte/metabolismo; Células Endoteliais da Veia Umbilical Humana/metabolismo; Albuminas/metabolismo

Palavras-chave

Apolipoprotein A4; Apolipoprotein M; LCMS/MS; Sphingosine 1-phosphate.Abbreviations: ApoA4, Apolipoprotein A4; ApoM, Apolipoprotein M; CHO, Chinese hamster ovary; ERK, Extracellular signal-regulated kinase; LCMS/MS, Liquid chromatographytandem mass spectrometry; LPP, Lipid phosphate phosphatase; Mfsd2b, Multiple facilitator superfamily domain containing 2B; PBS, Phosphate-buffered saline; S1P, Sphingosine 1-phosphate; S1PR1, Sphingosine 1-phosphate receptor 1; S1PR3, Sphingosine 1-phosphate receptor 3; SphK, Sphingosine kinase; Spns2, Spinster homolog 2; TBS-T, Tris-buffed saline containing 0.1% Tween20

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lisofosfolipídeos / Proteínas Proto-Oncogênicas c-akt Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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