Pseurotin A Validation as a Metastatic Castration-Resistant Prostate Cancer Recurrence-Suppressing Lead via PCSK9-LDLR Axis Modulation.

Abdelwahed, Khaldoun S; Siddique, Abu Bakar; Ebrahim, Hassan Y; Qusa, Mohammed H; Mudhish, Ethar A; Rad, Ashkan H; Zerfaoui, Mourad; Abd Elmageed, Zakaria Y; El Sayed, Khalid A

Abdelwahed, Khaldoun S; Siddique, Abu Bakar; Ebrahim, Hassan Y; Qusa, Mohammed H; Mudhish, Ethar A; Rad, Ashkan H; Zerfaoui, Mourad; Abd Elmageed, Zakaria Y; El Sayed, Khalid A.

Afiliação

Abdelwahed KS; School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.
Siddique AB; School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.
Ebrahim HY; School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.
Qusa MH; School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.
Mudhish EA; School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.
Rad AH; School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.
Zerfaoui M; Department of Surgery, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Abd Elmageed ZY; Department of Biomedical Sciences, Discipline of Pharmacology, Edward Via College of Osteopathic Medicine, University of Louisiana at Monroe, Monroe, LA 71203, USA.
El Sayed KA; School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.

Mar Drugs ; 21(4)2023 Mar 28.

Article em En | MEDLINE | ID: mdl-37103355

Assuntos

Pró-Proteína Convertase 9; Neoplasias de Próstata Resistentes à Castração; Humanos; Masculino; Camundongos; Animais; Idoso; Pró-Proteína Convertase 9/genética; Pró-Proteína Convertase 9/metabolismo; Camundongos Nus; Neoplasias de Próstata Resistentes à Castração/tratamento farmacológico; Serina Endopeptidases/metabolismo; Pró-Proteína Convertases/metabolismo; Antígeno Prostático Específico; Receptores de LDL/genética; Receptores de LDL/metabolismo; Colesterol

Palavras-chave

LDLR; PCSK9; castration-resistant prostate cancer; cholesterol; colony formation; fermentation; immunohistoscore; pseurotin A; recurrence; tissue microarray

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias de Próstata Resistentes à Castração / Pró-Proteína Convertase 9 Limite: Aged / Animals / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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