Sample size calculations for pathogen variant surveillance in the presence of biological and systematic biases.
Cell Rep Med
; 4(5): 101022, 2023 05 16.
Article
em En
| MEDLINE
| ID: mdl-37105175
ABSTRACT
Tracking the emergence and spread of pathogen variants is an important component of monitoring infectious disease outbreaks. To that end, accurately estimating the number and prevalence of pathogen variants in a population requires carefully designed surveillance programs. However, current approaches to calculating the number of pathogen samples needed for effective surveillance often do not account for the various processes that can bias which infections are detected and which samples are ultimately characterized as a specific variant. In this article, we introduce a framework that accounts for the logistical and epidemiological processes that may bias variant characterization, and we demonstrate how to use this framework (implemented in a publicly available tool) to calculate the number of sequences needed for surveillance. Our framework is designed to be easy to use while also flexible enough to be adapted to various pathogens and surveillance scenarios.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Surtos de Doenças
Tipo de estudo:
Risk_factors_studies
/
Screening_studies
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article