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Iron Deficiency and Iron Deficiency Anemia: Potential Risk Factors in Bone Loss.
Yang, Jiancheng; Li, Qingmei; Feng, Yan; Zeng, Yuhong.
Afiliação
  • Yang J; Department of Osteoporosis, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, China.
  • Li Q; Department of Osteoporosis, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, China.
  • Feng Y; Department of Osteoporosis, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, China.
  • Zeng Y; Department of Osteoporosis, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, China.
Int J Mol Sci ; 24(8)2023 Apr 07.
Article em En | MEDLINE | ID: mdl-37108056
Iron is one of the essential mineral elements for the human body and this nutrient deficiency is a worldwide public health problem. Iron is essential in oxygen transport, participates in many enzyme systems in the body, and is an important trace element in maintaining basic cellular life activities. Iron also plays an important role in collagen synthesis and vitamin D metabolism. Therefore, decrease in intracellular iron can lead to disturbance in the activity and function of osteoblasts and osteoclasts, resulting in imbalance in bone homeostasis and ultimately bone loss. Indeed, iron deficiency, with or without anemia, leads to osteopenia or osteoporosis, which has been revealed by numerous clinical observations and animal studies. This review presents current knowledge on iron metabolism under iron deficiency states and the diagnosis and prevention of iron deficiency and iron deficiency anemia (IDA). With emphasis, studies related to iron deficiency and bone loss are discussed, and the potential mechanisms of iron deficiency leading to bone loss are analyzed. Finally, several measures to promote complete recovery and prevention of iron deficiency are listed to improve quality of life, including bone health.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoporose / Anemia Ferropriva / Deficiências de Ferro Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoporose / Anemia Ferropriva / Deficiências de Ferro Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article