Three-Dimensional Structural Insights Have Revealed the Distinct Binding Interactions of Agonists, Partial Agonists, and Antagonists with the µ Opioid Receptor.

Li, Zoe; Liu, Jie; Dong, Fan; Chang, Nancy; Huang, Ruili; Xia, Menghang; Patterson, Tucker A; Hong, Huixiao

Li, Zoe; Liu, Jie; Dong, Fan; Chang, Nancy; Huang, Ruili; Xia, Menghang; Patterson, Tucker A; Hong, Huixiao.

Afiliação

Li Z; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
Liu J; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
Dong F; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
Chang N; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20903, USA.
Huang R; National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
Xia M; National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
Patterson TA; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
Hong H; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.

Int J Mol Sci ; 24(8)2023 Apr 11.

Article em En | MEDLINE | ID: mdl-37108204

Assuntos

Analgésicos Opioides; Receptores Opioides; Humanos; Analgésicos Opioides/metabolismo; Analgésicos; Dor; Sítios de Ligação; Receptores Opioides mu/metabolismo

Palavras-chave

agonist; antagonist; binding; structure; µ opioid receptor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Opioides / Analgésicos Opioides Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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