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Tuning the Biological Activity of PI3Kδ Inhibitor by the Introduction of a Fluorine Atom Using the Computational Workflow.
Pietrus, Wojciech; Stypik, Mariola; Zagozda, Marcin; Banach, Martyna; Gurba-Bryskiewicz, Lidia; Maruszak, Wioleta; Leniak, Arkadiusz; Kurczab, Rafal; Ochal, Zbigniew; Dubiel, Krzysztof; Wieczorek, Maciej.
Afiliação
  • Pietrus W; Department of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland.
  • Stypik M; Celon Pharma S.A., ul. Marymoncka 15, 05-152 Kazun Nowy, Poland.
  • Zagozda M; Celon Pharma S.A., ul. Marymoncka 15, 05-152 Kazun Nowy, Poland.
  • Banach M; Faculty of Chemistry, Warsaw University of Technology, ul. Nowakowskiego 3, 00-664 Warsaw, Poland.
  • Gurba-Bryskiewicz L; Celon Pharma S.A., ul. Marymoncka 15, 05-152 Kazun Nowy, Poland.
  • Maruszak W; Celon Pharma S.A., ul. Marymoncka 15, 05-152 Kazun Nowy, Poland.
  • Leniak A; Celon Pharma S.A., ul. Marymoncka 15, 05-152 Kazun Nowy, Poland.
  • Kurczab R; Celon Pharma S.A., ul. Marymoncka 15, 05-152 Kazun Nowy, Poland.
  • Ochal Z; Celon Pharma S.A., ul. Marymoncka 15, 05-152 Kazun Nowy, Poland.
  • Dubiel K; Department of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland.
  • Wieczorek M; Faculty of Chemistry, Warsaw University of Technology, ul. Nowakowskiego 3, 00-664 Warsaw, Poland.
Molecules ; 28(8)2023 Apr 17.
Article em En | MEDLINE | ID: mdl-37110764
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfatidilinositol 3-Quinases / Flúor Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfatidilinositol 3-Quinases / Flúor Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article