Investigating the role of double mutations R12C/P20R, and R12C/R69C on structure, chaperone-like activity, and amyloidogenic properties of human &#945;B-crystallin.

Khaleghinejad, Seyed Hossein; Shahsavani, Mohammad Bagher; Ghahramani, Maryam; Yousefi, Reza

Investigating the role of double mutations R12C/P20R, and R12C/R69C on structure, chaperone-like activity, and amyloidogenic properties of human αB-crystallin.

Khaleghinejad, Seyed Hossein; Shahsavani, Mohammad Bagher; Ghahramani, Maryam; Yousefi, Reza.

Afiliação

Khaleghinejad SH; Protein Chemistry Laboratory (PCL), Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
Shahsavani MB; Protein Chemistry Laboratory (PCL), Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
Ghahramani M; Protein Chemistry Laboratory (PCL), Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
Yousefi R; Protein Chemistry Laboratory (PCL), Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran; Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran. Electronic address: ryousefi@shirazu.ac.ir.

Int J Biol Macromol ; 242(Pt 1): 124590, 2023 Jul 01.

Article em En | MEDLINE | ID: mdl-37116845

Assuntos

Catarata; alfa-Cristalinas; Humanos; Catarata/genética; Cadeia B de alfa-Cristalina/genética; Cadeia B de alfa-Cristalina/química; Mutação; Dobramento de Proteína; alfa-Cristalinas/metabolismo

Palavras-chave

Amyloid fibril; Chaperone function; Human αB-crystallin; Mutation; Structure

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Catarata / Alfa-Cristalinas Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Catarata / Alfa-Cristalinas Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article