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Ellagic acid and its metabolites urolithins A/B ameliorate most common disease phenotypes in cellular and mouse models for lysosomal storage disorders by enhancing extracellular vesicle secretion.
Soto-Huelin, Beatriz; Babiy, Bohdan; Pastor, Oscar; Díaz-García, Mario; Toledano-Zaragoza, Ana; Frutos, María Dolores; Espín, Juan Carlos; Tomás-Barberán, Francisco A; Busto, Rebeca; Ledesma, María Dolores.
Afiliação
  • Soto-Huelin B; Centro Biología Molecular Severo Ochoa (CSIC-UAM), Madrid 28049, Spain.
  • Babiy B; Servicio de Bioquímica-Clínica, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid 28034, Spain.
  • Pastor O; Servicio de Bioquímica-Clínica, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid 28034, Spain.
  • Díaz-García M; Centro Biología Molecular Severo Ochoa (CSIC-UAM), Madrid 28049, Spain.
  • Toledano-Zaragoza A; Centro Biología Molecular Severo Ochoa (CSIC-UAM), Madrid 28049, Spain.
  • Frutos MD; Food and Health Laboratory, Department of Food Science and Technology, CEBAS-CSIC, Murcia 30100, Spain.
  • Espín JC; Food and Health Laboratory, Department of Food Science and Technology, CEBAS-CSIC, Murcia 30100, Spain.
  • Tomás-Barberán FA; Food and Health Laboratory, Department of Food Science and Technology, CEBAS-CSIC, Murcia 30100, Spain.
  • Busto R; Servicio de Bioquímica-Investigación, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid 28034, Spain. Electronic address: rebeca.busto@hrc.es.
  • Ledesma MD; Centro Biología Molecular Severo Ochoa (CSIC-UAM), Madrid 28049, Spain. Electronic address: dledesma@cbm.csic.es.
Neurobiol Dis ; 182: 106141, 2023 06 15.
Article em En | MEDLINE | ID: mdl-37121555
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças por Armazenamento dos Lisossomos / Doença de Niemann-Pick Tipo A / Vesículas Extracelulares Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças por Armazenamento dos Lisossomos / Doença de Niemann-Pick Tipo A / Vesículas Extracelulares Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article