Critical challenges and advances in recombinant adeno-associated virus (rAAV) biomanufacturing.

Fu, Qiang; Polanco, Ashli; Lee, Yong Suk; Yoon, Seongkyu

Fu, Qiang; Polanco, Ashli; Lee, Yong Suk; Yoon, Seongkyu.

Afiliação

Fu Q; Department of Biomedical Engineering and Biotechnology, The University of Massachusetts Lowell, Lowell, Massachusetts, USA.
Polanco A; Department of Chemical Engineering, The University of Massachusetts Lowell, Lowell, Massachusetts, USA.
Lee YS; Department of Pharmaceutical Sciences, The University of Massachusetts Lowell, Lowell, Massachusetts, USA.
Yoon S; Department of Chemical Engineering, The University of Massachusetts Lowell, Lowell, Massachusetts, USA.

Biotechnol Bioeng ; 120(9): 2601-2621, 2023 09.

Article em En | MEDLINE | ID: mdl-37126355

Assuntos

Dependovirus; Vetores Genéticos; Humanos; Dependovirus/genética; Vetores Genéticos/genética; Terapia Genética

Palavras-chave

capsid recovery; continuous manufacturing; gene therapy manufacturing; in silico modeling; inducible system; multiomics; recombinant AAV (rAAV)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dependovirus / Vetores Genéticos Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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