Human TFF2-Fc fusion protein alleviates DSS-induced ulcerative colitis in C57BL/6 mice by promoting intestinal epithelial cells repair and inhibiting macrophage inflammation.

Guo, Meng; Wang, Rongrong; Geng, Jiajia; Li, Zhen; Liu, Mingfei; Lu, Xuxiu; Wei, Jianteng; Liu, Ming

Guo, Meng; Wang, Rongrong; Geng, Jiajia; Li, Zhen; Liu, Mingfei; Lu, Xuxiu; Wei, Jianteng; Liu, Ming.

Afiliação

Guo M; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Wang R; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China.
Geng J; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Li Z; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China.
Liu M; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Lu X; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China.
Wei J; Jingyuan Biomedicine (Suzhou) Co., Ltd., Suzhou, 215000, China.
Liu M; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.

Inflammopharmacology ; 31(3): 1387-1404, 2023 Jun.

Article em En | MEDLINE | ID: mdl-37129719

Assuntos

Colite Ulcerativa; Fator Trefoil-2; Animais; Humanos; Camundongos; Células CACO-2; Colite Ulcerativa/induzido quimicamente; Colite Ulcerativa/tratamento farmacológico; Colite Ulcerativa/metabolismo; Colo/metabolismo; Sulfato de Dextrana; Modelos Animais de Doenças; Células Epiteliais/metabolismo; Peróxido de Hidrogênio/metabolismo; Inflamação/tratamento farmacológico; Inflamação/metabolismo; Mucosa Intestinal; Lipopolissacarídeos; Macrófagos/metabolismo; Camundongos Endogâmicos C57BL; Fator Trefoil-2/farmacologia; Células RAW 264.7

Palavras-chave

Inflammatory damage; Intestinal mucosa repair; Oxidative damage; TFF2-Fc; Ulcerative colitis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Colite Ulcerativa / Fator Trefoil-2 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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