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Ischemic tubular injury: Oxygen-sensitive signals and metabolic reprogramming.
Rahbar Saadat, Yalda; Hosseiniyan Khatibi, Seyed Mahdi; Sani, Anis; Zununi Vahed, Sepideh; Ardalan, Mohammadreza.
Afiliação
  • Rahbar Saadat Y; Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Hosseiniyan Khatibi SM; Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Sani A; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Zununi Vahed S; Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. sepide.zununi@gmail.com.
  • Ardalan M; Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ardalan34@yahoo.com.
Inflammopharmacology ; 31(4): 1657-1669, 2023 Aug.
Article em En | MEDLINE | ID: mdl-37131045
The kidneys are the most vulnerable organs to severe ischemic insult that results in cellular hypoxia under pathophysiological conditions. Large amounts of oxygen are consumed by the kidneys, mainly to produce energy for tubular reabsorption. Beyond high oxygen demand and the low oxygen supply, different other factors make kidneys vulnerable to ischemia which is deemed to be a major cause of acute kidney injury (AKI). On the other hand, kidneys are capable of sensing and responding to oxygen alternations to evade harms resulting from inadequate oxygen. The hypoxia-inducible factor (HIF) is the main conserved oxygen-sensing mechanism that maintains homeostasis under hypoxia through direct/indirect regulation of several genes that contribute to metabolic adaptation, angiogenesis, energy conservation, erythropoiesis, and so on. In response to oxygen availability, prolyl-hydroxylases (PHDs) control the HIF stability. This review focuses on the oxygen-sensing mechanisms in kidneys, particularly in proximal tubular cells (PTCs) and discusses the molecules involved in ischemic response and metabolic reprogramming. Moreover, the possible roles of non-coding RNAs (microRNAs and long non-coding RNAs) in the development of ischemic AKI are put forward.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxigênio / Injúria Renal Aguda Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxigênio / Injúria Renal Aguda Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article