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Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer.
Xu, Zhiwen; Goel, Hira Lal; Burkart, Christoph; Burman, Luke; Chong, Yeeting E; Barber, Alison G; Geng, Yanyan; Zhai, Liting; Wang, Mengdie; Kumar, Ayush; Menefee, Ann; Polizzi, Clara; Eide, Lisa; Rauch, Kaitlyn; Rahman, Justin; Hamel, Kristina; Fogassy, Zachary; Klopp-Savino, Sofia; Paz, Suzanne; Zhang, Mingjie; Cubitt, Andrea; Nangle, Leslie A; Mercurio, Arthur M.
Afiliação
  • Xu Z; aTyr Pharma, San Diego, CA 92121, USA.
  • Goel HL; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Burkart C; aTyr Pharma, San Diego, CA 92121, USA.
  • Burman L; aTyr Pharma, San Diego, CA 92121, USA.
  • Chong YE; aTyr Pharma, San Diego, CA 92121, USA.
  • Barber AG; aTyr Pharma, San Diego, CA 92121, USA.
  • Geng Y; IAS HKUST - Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
  • Zhai L; Pangu Biopharma, 26th Floor, Three Exchange Square, 8 Connaught Place, Central, Hong Kong, China.
  • Wang M; IAS HKUST - Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
  • Kumar A; Pangu Biopharma, 26th Floor, Three Exchange Square, 8 Connaught Place, Central, Hong Kong, China.
  • Menefee A; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Polizzi C; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
  • Eide L; aTyr Pharma, San Diego, CA 92121, USA.
  • Rauch K; aTyr Pharma, San Diego, CA 92121, USA.
  • Rahman J; aTyr Pharma, San Diego, CA 92121, USA.
  • Hamel K; aTyr Pharma, San Diego, CA 92121, USA.
  • Fogassy Z; aTyr Pharma, San Diego, CA 92121, USA.
  • Klopp-Savino S; aTyr Pharma, San Diego, CA 92121, USA.
  • Paz S; aTyr Pharma, San Diego, CA 92121, USA.
  • Zhang M; aTyr Pharma, San Diego, CA 92121, USA.
  • Cubitt A; aTyr Pharma, San Diego, CA 92121, USA.
  • Nangle LA; IAS HKUST - Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
  • Mercurio AM; aTyr Pharma, San Diego, CA 92121, USA.
Sci Transl Med ; 15(694): eadf1128, 2023 05 03.
Article em En | MEDLINE | ID: mdl-37134152
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neuropilina-2 / Neoplasias de Mama Triplo Negativas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neuropilina-2 / Neoplasias de Mama Triplo Negativas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article