Effects of hyaluronic acid and chondroitin sulfate on acute radiation proctitis in rats.
Ulus Travma Acil Cerrahi Derg
; 29(5): 547-552, 2023 May.
Article
em En
| MEDLINE
| ID: mdl-37145048
ABSTRACT
BACKGROUND:
This study was designed to investigate the prophylactic and therapeutic effects of hyaluronic acid and chondroitin sulfate combination (HA/CS) on a model of acute radiation proctitis.METHODS:
Rats were divided into five groups SHAM; irradiation (IR) + saline (1 mL for 5th and 10th day); IR + HA/CS (1 mL for 5th and 10th day). A single fraction of 17.5 Gy was delivered to each rat. HA/CS was administered rectally each day after irradiation. Each rat was observed daily for signs of proctitis. Irradiated rats were euthanized on days 5 and 10. The mucosal changes were evaluated macroscopically and pathologically.RESULTS:
According to the clinical findings, five rats in the irradiation + saline group showed grade 3-4 symptoms on the 10th day. No significant difference in the macroscopic finding scores on the 5th day was observed between the irradiation + saline and irradiation + HA/CS groups. In the pathological examination, radiation-induced mucosal damage was the most prominent finding 10 days after irradiation in saline-treated rats. On the 10th day, the irradiation + HA/CS group showed mild inflammation and slight crypt changes, which corresponded to grade 1-2 pathological findings.CONCLUSION:
We think that HA/CS used in radiation cystitis can be beneficial for radiation proctitis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proctite
/
Ácido Hialurônico
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article