Long Duration of Action of Tranexamic Acid After Cardiac Surgery in a Hemodialysis Patient: A Case Report.
A A Pract
; 17(5): e01676, 2023 May 01.
Article
em En
| MEDLINE
| ID: mdl-37146220
ABSTRACT
A 61-year-old woman with chronic renal dysfunction was scheduled to undergo aortic valve replacement. After a bolus of 1 g tranexamic acid (TXA), the TPA (tissue-plasminogen activator)-test result with the ClotPro system demonstrated extensive inhibition of fibrinolysis. Plasma TXA level decreased from 71 to 25 µg/dL at 6 hours postoperatively; however, no further decrease was observed. Although TXA levels dropped to 6.9 µg/dL after hemodialysis on postoperative day (PoD) 1, fibrinolytic shutdown on the TPA-test remained unchanged until PoD 2. In dialysis patients, low-dose TXA <1 g may be considered for reducing seizure and thromboembolic complications after cardiac surgery.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácido Tranexâmico
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Procedimentos Cirúrgicos Cardíacos
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Antifibrinolíticos
Limite:
Female
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article