Hybrid lipid-biopolymer nanocarrier as a strategy for GBM photodynamic therapy (PDT).
Int J Biol Macromol
; 242(Pt 1): 124647, 2023 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-37146851
ABSTRACT
Glioblastoma (GBM) is the most common brain cancer characterized by aggressive and infiltrated tumors. For this, hybrid biopolymer-lipid nanoparticles coated with biopolymers such as chitosan and lipidic nanocarriers (LN) loaded with a photosensitizer (AlClPc) can be used for GBM photodynamic therapy. The chitosan-coated LN exhibited stable physicochemical characteristics and presented as an excellent lipid nanocarrier with highly efficiently encapsulated photosensitizer chloro-aluminum phthalocyanine (AlClPc). LN(AlClPc)Ct0.1% in the presence of light produced more reactive oxygen species and reduced brain tumor cell viability and proliferation. Confirm the effects of in vivo LN applications with photodynamic therapy confirmed that the total brain tumor area decreased without systemic toxicity in mice. These results suggest a promising strategy for future clinical applications to improve brain cancer treatment.
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MEDLINE
Assunto principal:
Fotoquimioterapia
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Neoplasias Encefálicas
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Glioblastoma
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Quitosana
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Nanopartículas
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article