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Unusual presentations of chronic graft versus host disease.
Okorie, Chiamaka L; Salem, Iman; Scripture, Andrew J; Simmons, Brian J; Momtahen, Shabnam; Yan, Shaofeng.
Afiliação
  • Okorie CL; Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire, USA.
  • Salem I; Department of Dermatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA.
  • Scripture AJ; Department of Dermatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA.
  • Simmons BJ; Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire, USA.
  • Momtahen S; Department of Dermatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA.
  • Yan S; Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire, USA.
J Cutan Pathol ; 51(1): 15-19, 2024 Jan.
Article em En | MEDLINE | ID: mdl-37150830
ABSTRACT
Skin is commonly affected by graft versus host disease (GVHD), a complication of bone marrow transplantation (BMT). One-third of hematopoietic cell transplantation recipients develop acute eruption classically described as folliculocentric, maculopapular, or morbilliform, in contrast to the more common chronic presentations of sclerotic, poikilodermic, or lichenoid dermatitides. With the wider use of non-myeloablative (reduced-intensity) transplant therapy, various atypical presentations can occur, representing a diagnostic challenge. Herein, we report an unusual case of chronic GVHD manifested by two distinct clinical and histopathological features lacking the classical presentation. Five months after her BMT, the patient presented with a papulosquamous eruption on her neck, trunk, and arms showing a psoriasiform histopathological pattern of chronic GVHD. She also demonstrated multiple small flesh-colored papules on her distal extremities showing a solitary syringotropic pattern of GVHD, demonstrated by interface dermatitis involving the superficial eccrine duct, as the only diagnostic histopathological feature of GVHD. This report, with review of literature, highlights the uncommon psoriasiform GVHD and the novel description of isolated syringotropic chronic GVHD.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Psoríase / Exantema / Síndrome de Bronquiolite Obliterante / Doença Enxerto-Hospedeiro Limite: Female / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Psoríase / Exantema / Síndrome de Bronquiolite Obliterante / Doença Enxerto-Hospedeiro Limite: Female / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article