Aerobic CuBr2-Catalyzed Oxidative Coupling Reaction of Amidines with Exocyclic α,ß-Unsaturated Cycloketones for the Synthesis of Spiroimidazolines.
J Org Chem
; 88(11): 6729-6735, 2023 Jun 02.
Article
em En
| MEDLINE
| ID: mdl-37155411
ABSTRACT
A CuBr2-catalyzed cascade reaction of amidines with exocyclic α,ß-unsaturated cycloketones was developed, affording a large variety of spiroimidazolines in moderate to excellent yields. The reaction process involved the Michael addition and copper(II)-catalyzed aerobic oxidative coupling, in which O2 from air acted as the oxidant and H2O was the sole byproduct.
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MEDLINE
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En
Ano de publicação:
2023
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Article