Nintedanib Ameliorates Bleomycin-Induced Pulmonary Fibrosis, Inflammation, Apoptosis, and Oxidative Stress by Modulating PI3K/Akt/mTOR Pathway in Mice.

Pan, Lin; Cheng, Yiju; Yang, Wenting; Wu, Xiao; Zhu, Honglan; Hu, Meigui; Zhang, Yuquan; Zhang, Menglin

Pan, Lin; Cheng, Yiju; Yang, Wenting; Wu, Xiao; Zhu, Honglan; Hu, Meigui; Zhang, Yuquan; Zhang, Menglin.

Afiliação

Pan L; Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China.
Cheng Y; Department of Respiratory and Critical Care Medicine, Guiyang First People's Hospital, Guiyang, 550004, China. chengchengyiju@126.com.
Yang W; Guizhou Medical University, Guiyang, 550004, China. chengchengyiju@126.com.
Wu X; Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China. 807580186@qq.com.
Zhu H; Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China.
Hu M; Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China.
Zhang Y; Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China.
Zhang M; Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China.

Inflammation ; 46(4): 1531-1542, 2023 Aug.

Article em En | MEDLINE | ID: mdl-37160579

Assuntos

Fibrose Pulmonar Idiopática; Animais; Humanos; Camundongos; Antioxidantes/farmacologia; Apoptose; Bleomicina/farmacologia; Colágeno/metabolismo; Fibrose Pulmonar Idiopática/induzido quimicamente; Fibrose Pulmonar Idiopática/tratamento farmacológico; Fibrose Pulmonar Idiopática/metabolismo; Inflamação/induzido quimicamente; Inflamação/tratamento farmacológico; Inflamação/metabolismo; Pulmão/metabolismo; Estresse Oxidativo; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Serina-Treonina Quinases TOR/metabolismo; Fator A de Crescimento do Endotélio Vascular/metabolismo

Palavras-chave

Apoptosis; Bleomycin; Nintedanib; Oxidative stress; PI3K/Akt/mTOR pathway.; Pulmonary fibrosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar Idiopática Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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