Nickel-Catalyzed Alkylation of Oxindoles with Secondary Alcohols.
J Org Chem
; 88(11): 7162-7171, 2023 Jun 02.
Article
em En
| MEDLINE
| ID: mdl-37161856
ABSTRACT
Herein, we have demonstrated a simple nickel-catalyzed C-3-selective alkylation of 2-oxindoles using a wide variety of secondary alkyl alcohols. As a special highlight, functionalization of the cholesterol derivative was reported. Control experiments, initial mechanistic studies, and deuterium-labeling experiments were performed for the alkylation process.
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MEDLINE
Idioma:
En
Ano de publicação:
2023
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Article