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Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036.
Xu, Jie; Lim, Ngiap-Kie; Timmerman, Jacob C; Shen, Jeff; Clagg, Kyle; Orcel, Ugo; Bigler, Raphael; Trachsel, Etienne; Meier, Roland; White, Nicholas A; Burkhard, Johannes A; Sirois, Lauren E; Tian, Qingping; Angelaud, Remy; Bachmann, Stephan; Zhang, Haiming; Gosselin, Francis.
Afiliação
  • Xu J; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Lim NK; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Timmerman JC; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Shen J; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Clagg K; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Orcel U; Department of Process Chemistry and Catalysis, F. Hoffmann-La Roche Ltd, Basel 4070, Switzerland.
  • Bigler R; Department of Process Chemistry and Catalysis, F. Hoffmann-La Roche Ltd, Basel 4070, Switzerland.
  • Trachsel E; Department of Process Chemistry and Catalysis, F. Hoffmann-La Roche Ltd, Basel 4070, Switzerland.
  • Meier R; Department of Solid State Sciences, F. Hoffmann-La Roche Ltd, Basel 4070, Switzerland.
  • White NA; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Burkhard JA; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Sirois LE; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Tian Q; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Angelaud R; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Bachmann S; Department of Process Chemistry and Catalysis, F. Hoffmann-La Roche Ltd, Basel 4070, Switzerland.
  • Zhang H; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Gosselin F; Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Org Lett ; 25(19): 3417-3422, 2023 May 19.
Article em En | MEDLINE | ID: mdl-37162129
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article