Evaluation of Gradient Concentration Strips for Detection of Terbinafine Resistance in Trichophyton spp.
Antimicrob Agents Chemother
; 67(6): e0171622, 2023 06 15.
Article
em En
| MEDLINE
| ID: mdl-37162356
ABSTRACT
The number of dermatophytosis cases resistant to terbinafine is increasing all over the world. Therefore, there is a need for antifungal susceptibility testing of dermatophytes for better management of the patients. In the present study, we have evaluated a gradient test (GT) method for testing the susceptibility of dermatophytes to terbinafine. MIC values to terbinafine determined by the EUCAST reference technique and by gradient test were compared for 79 Trichophyton spp. isolates. Overall, MICs were lower with gradient test (MIC50 of 0.002 µg/mL) than with EUCAST (MIC50 of 0.016 µg/mL). Good categorical agreement (>90%) between the 2 techniques was obtained but the essential agreement was variable depending on the batch of gradient test.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Tinha
/
Arthrodermataceae
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article