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Use of Developmental Midazolam and 1-Hydroxymidazolam Data with Pediatric Physiologically Based Modeling to Assess Cytochrome P450 3A4 and Uridine Diphosphate Glucuronosyl Transferase 2B4 Ontogeny In Vivo.
Johnson, Trevor N; Howgate, Eleanor M; de Wildt, Saskia N; Turner, Mark A; Rowland Yeo, Karen.
Afiliação
  • Johnson TN; Certara UK Limited (Simcyp Division), Sheffield, United Kingdom (T.N.J., E.M.H., K.R.Y.); Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, Netherlands (S.N.dW.); and Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingd
  • Howgate EM; Certara UK Limited (Simcyp Division), Sheffield, United Kingdom (T.N.J., E.M.H., K.R.Y.); Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, Netherlands (S.N.dW.); and Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingd
  • de Wildt SN; Certara UK Limited (Simcyp Division), Sheffield, United Kingdom (T.N.J., E.M.H., K.R.Y.); Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, Netherlands (S.N.dW.); and Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingd
  • Turner MA; Certara UK Limited (Simcyp Division), Sheffield, United Kingdom (T.N.J., E.M.H., K.R.Y.); Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, Netherlands (S.N.dW.); and Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingd
  • Rowland Yeo K; Certara UK Limited (Simcyp Division), Sheffield, United Kingdom (T.N.J., E.M.H., K.R.Y.); Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, Netherlands (S.N.dW.); and Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingd
Drug Metab Dispos ; 51(8): 1035-1045, 2023 Aug.
Article em En | MEDLINE | ID: mdl-37169511

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Midazolam / Citocromo P-450 CYP3A Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Child / Child, preschool / Humans / Infant / Newborn Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Midazolam / Citocromo P-450 CYP3A Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Child / Child, preschool / Humans / Infant / Newborn Idioma: En Ano de publicação: 2023 Tipo de documento: Article