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Jointly Depleting Glutathione Based on Self-Assembled Nanomicelles for Enhancing Photodynamic Therapy.
Wu, Jingxi; Shang, Jingjing; An, Jing; Chen, Wenlong; Hong, Gaobo; Hou, Haoran; Zheng, Wen-Heng; Song, Fengling; Peng, Xiaojun.
Afiliação
  • Wu J; State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian, 116024, China.
  • Shang J; State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian, 116024, China.
  • An J; State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian, 116024, China.
  • Chen W; State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian, 116024, China.
  • Hong G; State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian, 116024, China.
  • Hou H; State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian, 116024, China.
  • Zheng WH; Department of Interventional Therapy, Cancer Hospital of, Dalian University of Technology, Liaoning Cancer Hospital and Institute, Shenyang, 110042, China.
  • Song F; State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian, 116024, China.
  • Peng X; Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao, 266237, China.
Chembiochem ; 24(16): e202300323, 2023 08 15.
Article em En | MEDLINE | ID: mdl-37169724
ABSTRACT
Photodynamic therapy (PDT) is one common ROS-generating therapeutic method with high tumor selectivity and low side effects. But the GSH-upregulation often alleviates its therapeutic efficiency. Here, we proposed a new strategy of jointly depleting GSH to enhance the therapeutic effect of PDT by preparing a nanomicelle by self-assembly method from GSH-activated photosensitizer DMT, curcumin, and amphiphilic polymer TPGS.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Curcumina / Nanopartículas / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Curcumina / Nanopartículas / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article