Cryptadine C, a new C<sub>27</sub>N<sub>3</sub>-type Lycopodium alkaloid from Lycopodium cryptomerinum.

Hirasawa, Yusuke; Hattori, Rina; Ohtani, Manami; Morita, Hiroshi

Cryptadine C, a new C₂₇N₃-type Lycopodium alkaloid from Lycopodium cryptomerinum.

Hirasawa, Yusuke; Hattori, Rina; Ohtani, Manami; Morita, Hiroshi.

Afiliação

Hirasawa Y; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-Ku, Tokyo, 142-8501, Japan. y-hirasawa@hoshi.ac.jp.
Hattori R; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-Ku, Tokyo, 142-8501, Japan.
Ohtani M; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-Ku, Tokyo, 142-8501, Japan.
Morita H; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-Ku, Tokyo, 142-8501, Japan. moritah@hoshi.ac.jp.

J Nat Med ; 77(3): 610-613, 2023 Jun.

Article em En | MEDLINE | ID: mdl-37171655

ABSTRACT

ABSTRACT

A new C27N3-type Lycopodium alkaloid consisting of two decahydroquinolines and a piperidine, cryptadine C (1) was isolated from Lycopodium cryptomerinum. The structure and relative configuration of 1, which is related to those of cryptadines A and B, lycoperine A, and hupercumine A, was elucidated on the basis of spectroscopic data. Cryptadine C showed moderate inhibitory activity against acetylcholinesterase.

Assuntos

Alcaloides; Lycopodium; Lycopodium/química; Acetilcolinesterase; Alcaloides/farmacologia; Alcaloides/química

Palavras-chave

Acetylcholinesterase; Cryptadine C; Lycopodium alkaloid; Lycopodium cryptomerinum

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lycopodium / Alcaloides Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lycopodium / Alcaloides Idioma: En Ano de publicação: 2023 Tipo de documento: Article