Quality control and analytic best practices for testing genetic models of sex differences in large populations.
Cell
; 186(10): 2044-2061, 2023 05 11.
Article
em En
| MEDLINE
| ID: mdl-37172561
ABSTRACT
Phenotypic sex-based differences exist for many complex traits. In other cases, phenotypes may be similar, but underlying biology may vary. Thus, sex-aware genetic analyses are becoming increasingly important for understanding the mechanisms driving these differences. To this end, we provide a guide outlining the current best practices for testing various models of sex-dependent genetic effects in complex traits and disease conditions, noting that this is an evolving field. Insights from sex-aware analyses will not only teach us about the biology of complex traits but also aid in achieving the goals of precision medicine and health equity for all.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Caracteres Sexuais
/
Modelos Genéticos
Tipo de estudo:
Guideline
/
Prognostic_studies
Limite:
Animals
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Female
/
Humans
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Male
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article