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A review of the antiviral activity of cationic antimicrobial peptides.
Urmi, Umme Laila; Vijay, Ajay Kumar; Kuppusamy, Rajesh; Islam, Salequl; Willcox, Mark D P.
Afiliação
  • Urmi UL; School of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: m.urmi@unsw.edu.au.
  • Vijay AK; School of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: v.ajaykumar@unsw.edu.au.
  • Kuppusamy R; School of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia; School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: r.kuppusamy@unsw.edu.au.
  • Islam S; School of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia; Department of Microbiology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh. Electronic address: salequl@juniv.edu.
  • Willcox MDP; School of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: m.willcox@unsw.edu.au.
Peptides ; 166: 171024, 2023 Aug.
Article em En | MEDLINE | ID: mdl-37172781
Viral epidemics are occurring frequently, and the COVID-19 viral pandemic has resulted in at least 6.5 million deaths worldwide. Although antiviral therapeutics are available, these may not have sufficient effect. The emergence of resistant or novel viruses requires new therapies. Cationic antimicrobial peptides are agents of the innate immune system that may offer a promising solution to viral infections. These peptides are gaining attention as possible therapies for viral infections or for use as prophylactic agents to prevent viral spread. This narrative review examines antiviral peptides, their structural features, and mechanism of activity. A total of 156 cationic antiviral peptides were examined for information of their mechanism of action against both enveloped and non-enveloped viruses. Antiviral peptides can be isolated from various natural sources or can be generated synthetically. The latter tend to be more specific and effective and can be made to have a broad spectrum of activity with minimal side effects. Their unique properties of being positively charged and amphipathic enable their main mode of action which is to target and disrupt viral lipid envelopes, thereby inhibiting viral entry and replication. This review offers a comprehensive summary of the current understanding of antiviral peptides, which could potentially aid in the design and creation of novel antiviral medications.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus / Viroses / COVID-19 Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus / Viroses / COVID-19 Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article