Synthesis of new multitarget-directed ligands containing thienopyrimidine nucleus for inhibition of 15-lipoxygenase, cyclooxygenases, and pro-inflammatory cytokines.

Abdelkhalek, Ahmed S; Kothayer, Hend; Rezq, Samar; Orabi, Khaled Y; Romero, Damian G; El-Sabbagh, Osama I

Abdelkhalek, Ahmed S; Kothayer, Hend; Rezq, Samar; Orabi, Khaled Y; Romero, Damian G; El-Sabbagh, Osama I.

Afiliação

Abdelkhalek AS; Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.
Kothayer H; Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt. Electronic address: hendo1311@hotmail.com.
Rezq S; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Egypt; Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, USA; Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center, Jackson,
Orabi KY; Department of Pharmaceutical Chemistry, College of Pharmacy, Health Sciences Center, Kuwait University, 13110, Safat, Kuwait.
Romero DG; Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, USA; Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center, Jackson, MS, USA; Women's Health Research Center, University of Mississippi Medical Center, Jackson,
El-Sabbagh OI; Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.

Eur J Med Chem ; 256: 115443, 2023 Aug 05.

Article em En | MEDLINE | ID: mdl-37182334

Assuntos

Inibidores de Ciclo-Oxigenase 2; Diclofenaco; Celecoxib; Ciclo-Oxigenase 2/metabolismo; Inibidores de Ciclo-Oxigenase 2/química; Citocinas; Araquidonato 15-Lipoxigenase; Fator de Necrose Tumoral alfa; Interleucina-6; Espécies Reativas de Oxigênio; Simulação de Acoplamento Molecular; Anti-Inflamatórios; Pirimidinas/farmacologia; Relação Estrutura-Atividade; Inibidores de Lipoxigenase/química

Palavras-chave

15-LOX/ COX-2 enzymes; Celecoxib; Diclofenac; Docking study; Synthesis; Thieno[2,3-d]pyrimidine derivatives

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diclofenaco / Inibidores de Ciclo-Oxigenase 2 Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diclofenaco / Inibidores de Ciclo-Oxigenase 2 Idioma: En Ano de publicação: 2023 Tipo de documento: Article