Anti-inflammatory ent-cleistanthane-type diterpenoids from Phyllanthus rheophyticus.
Phytochemistry
; 212: 113723, 2023 Aug.
Article
em En
| MEDLINE
| ID: mdl-37182686
ABSTRACT
A bioactivity-guided isolation from the aerial parts of Phyllanthus rheophyticus obtained 17 undescribed ent-cleistanthane-type diterpenoids, namely phyllarheophols A-Q, as well as 12 known analogs. Their structures were characterized by a combination of spectroscopic data interpretation, single-crystal X-ray diffraction and ECD analysis. The anti-inflammatory activities of these compounds were evaluated by measuring their inhibitory effects on NO production in LPS-stimulated RAW264.7 macrophages, and their preliminary structure-activity relationships were also discussed. Further study showed that promising compounds phyllarheophol D and phyacioid B significantly suppressed the expressions of cytokines and nitric oxide synthase through the NF-κB signaling pathway.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Phyllanthus
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Diterpenos
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Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article