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Reduced APPL1 impairs osteogenic differentiation of mesenchymal stem cells by facilitating MGP expression to disrupt the BMP2 pathway in osteoporosis.
Yuan, Weiquan; Liu, Wenjie; Zhang, Yunhui; Wang, Xinglang; Xu, Chenhao; Li, Quanfeng; Ji, Pengfei; Wang, Jiaxin; Feng, Pei; Wu, Yanfeng; Shen, Huiyong; Wang, Peng.
Afiliação
  • Yuan W; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
  • Liu W; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
  • Zhang Y; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
  • Wang X; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
  • Xu C; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
  • Li Q; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
  • Ji P; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
  • Wang J; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
  • Feng P; Center for Biotherapy, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
  • Wu Y; Center for Biotherapy, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China. Electronic address: wuyf@mail.sysu.edu.cn.
  • Shen H; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China. Electronic address: shenhuiy@mail.sysu.edu.cn.
  • Wang P; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China. Electronic address: wangp57@mail.sysu.edu.cn.
J Biol Chem ; 299(6): 104823, 2023 06.
Article em En | MEDLINE | ID: mdl-37187293
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoporose / Proteínas de Ligação ao Cálcio / Proteínas Adaptadoras de Transdução de Sinal / Células-Tronco Mesenquimais Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoporose / Proteínas de Ligação ao Cálcio / Proteínas Adaptadoras de Transdução de Sinal / Células-Tronco Mesenquimais Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article