A voltammetric sensor based on a reduced graphene oxide/ß-cyclodextrin/silver nanoparticle/polyoxometalate nanocomposite for detecting uric acid and tyrosine.

ABSTRACT

In the present work, an electrochemical sensor based on reduced graphene oxide/ß-cyclodextrin/silver nanoparticle/polyoxometalate (RGO-CD-AgNP-POM) was developed for the simultaneous detection of uric acid (UA) and L-tyrosine (L-Tyr). First, an RGO-CD-AgNP-POM nanocomposite was synthesized via a simple photoreduction method and characterized by transmission electron microscopy (TEM), energy dispersive X-ray imaging (EDS), scanning electron microscopy (SEM), and thermal gravimetric analysis (TGA). As an electrode material, RGO-CD-AgNP-POM showed wide linear ranges (0.5-500 µM for UA, and 1-400 µM for L-Tyr) and relatively low detection limits (0.11 µM for UA, and 0.23 µM for L-Tyr). In addition, the combination of supramolecular recognition from CD and excellent electrochemical performances from RGO, AgNPs and POM was expected to enhance the sensing performances toward UA and L-Tyr in real samples with favorable recovery ranges (99%-104%). This nanocomposite provides a new platform for developing the family of electrode materials.