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Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1.
Zhou, Xiang; Han, Seungbin; Cebulla, Nadine; Haertle, Larissa; Steinhardt, Maximilian J; Schirmer, Daniel; Runau, Eva; Flamm, Leon; Terhorst, Calvin; Jähnel, Laura; Vogt, Cornelia; Nerreter, Silvia; Teufel, Eva; Stanojkovska, Emilia; Mersi, Julia; Munawar, Umair; Schindehütte, Magnus; Blum, Robert; Reinhold, Ann-Kristin; Scherf-Clavel, Oliver; Rittner, Heike L; Pham, Mirko; Rasche, Leo; Einsele, Hermann; Sommer, Claudia; Kortüm, K Martin.
Afiliação
  • Zhou X; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.
  • Han S; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.
  • Cebulla N; Department of Neurology, University Hospital of Würzburg, Würzburg, Germany.
  • Haertle L; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.
  • Steinhardt MJ; Department of Hematology, Spanish National Cancer Research Center (CNIO), Hospital Universitario 12 de Octubre, Complutense University Madrid, Madrid, Spain.
  • Schirmer D; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.
  • Runau E; Department of Neurology, University Hospital of Würzburg, Würzburg, Germany.
  • Flamm L; Department of Neurology, University Hospital of Würzburg, Würzburg, Germany.
  • Terhorst C; Department of Neurology, University Hospital of Würzburg, Würzburg, Germany.
  • Jähnel L; Department of Neurology, University Hospital of Würzburg, Würzburg, Germany.
  • Vogt C; Department of Neurology, University Hospital of Würzburg, Würzburg, Germany.
  • Nerreter S; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.
  • Teufel E; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.
  • Stanojkovska E; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.
  • Mersi J; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.
  • Munawar U; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.
  • Schindehütte M; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.
  • Blum R; Department of Neuroradiology, University Hospital of Würzburg, Würzburg, Germany.
  • Reinhold AK; Department of Neurology, University Hospital of Würzburg, Würzburg, Germany.
  • Scherf-Clavel O; Center for Interdisciplinary Medicine, Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital of Würzburg, Würzburg, Germany.
  • Rittner HL; Department of Clinical Pharmacy, University of Würzburg, Würzburg, Germany.
  • Pham M; Center for Interdisciplinary Medicine, Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital of Würzburg, Würzburg, Germany.
  • Rasche L; Department of Neuroradiology, University Hospital of Würzburg, Würzburg, Germany.
  • Einsele H; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.
  • Sommer C; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.
  • Kortüm KM; Department of Neurology, University Hospital of Würzburg, Würzburg, Germany.
Biomark Res ; 11(1): 52, 2023 May 16.
Article em En | MEDLINE | ID: mdl-37194045
ABSTRACT
We analyzed single nucleotide polymorphisms (SNPs) in PKNOX1 (rs2839629) and in the intergenic region between PKNOX1 and CBS (rs915854) by Sanger sequencing in 88 patients with multiple myeloma treated with bortezomib. All patients (n = 13) harboring a homozygous mutation in PKNOX1 (rs2839629) also had a homozygous mutated rs915854 genotype. Homozygous mutated genotypes of rs2839629 and rs915854 were significantly enriched in patients with painful peripheral neuropathy (PNP) (P < 0.0001), and homozygous mutated rs2839629 genotype was significantly enriched in patients with pain compared to patients with no pain (P = 0.04). In summary, both SNPs rs2839629 and/or rs915854 may be potential biomarkers predicting an increased risk to develop painful PNP under bortezomib.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article