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Discovery of Novel Bruton's Tyrosine Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy.
Li, Yi-Qian; Lannigan, William G; Davoodi, Shabnam; Daryaee, Fereidoon; Corrionero, Ana; Alfonso, Patricia; Rodriguez-Santamaria, Jose A; Wang, Nan; Haley, John D; Tonge, Peter J.
Afiliação
  • Li YQ; Center for Advanced Study of Drug Action, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.
  • Lannigan WG; Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.
  • Davoodi S; Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.
  • Daryaee F; Center for Advanced Study of Drug Action, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.
  • Corrionero A; Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.
  • Alfonso P; Center for Advanced Study of Drug Action, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.
  • Rodriguez-Santamaria JA; Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.
  • Wang N; Enzymlogic S.L., QUBE Technology Park, C/ Santiago Grisolía, 2, Madrid 28760, Spain.
  • Haley JD; Enzymlogic S.L., QUBE Technology Park, C/ Santiago Grisolía, 2, Madrid 28760, Spain.
  • Tonge PJ; Enzymlogic S.L., QUBE Technology Park, C/ Santiago Grisolía, 2, Madrid 28760, Spain.
J Med Chem ; 66(11): 7454-7474, 2023 06 08.
Article em En | MEDLINE | ID: mdl-37195170
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Linfócitos B / Quimera de Direcionamento de Proteólise Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Linfócitos B / Quimera de Direcionamento de Proteólise Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article